Richard J. Cenedella, PhD

Emeritus Professor

Work: 660.626.2347
Email Address:

Research Interests: Dr. Cenedella is investigating molecular mechanisms of cataract formation, the leading worldwide cause of blindness. His work focuses on the structure and function of ocular lens membrane, the cellular site where he believes cataracts begin.


PhD - Jefferson Medical College (1966)

Scholarly Activity

Research Publications:

2009 | Cenedella RJ. Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. Lipids. 2009 Jun;44(6):477-87. Epub 2009 May 14

2009 | Dowling S, Cox J, Cenedella RJ. Inhibition of fatty acid synthase by orlistat accelerates gastric tumor cell apoptosis in culture and increases survival rates in gastric tumor bearing mice in vivo. Lipids. 2009 Jun;44(6):489-98. Epub 2009 Apr 21

2007 | Cenedella RJ, Sexton PS, Brako L, Lo WK, Jacob RF. Status of caveolin-1 in various membrane domains of the bovine lens. Exp Eye Res. 2007 Oct;85(4):473-81. Epub 2007 Jun 28

2005 | Cenedella RJ, Neely AR, Sexton P. Multiple forms of 22kDa caveolin-1 alpha present in bovine lens cells could reflect variable palmitoylation. Exp Eye Res. 2006 Feb;82(2):229-35. Epub 2005 Aug 25

2005 | Cenedella RJ, Sexton PS, Krishnan K, Covey DF. Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. Lipids. 2005 Jun;40(6):635-40

2005 | Cenedella RJ, Neely AR, Sexton P. Concentration and distribution of ubiquinone (coenzyme Q), the endogenous lipid antioxidant, in the rat lens: effect of treatment with simvastatin. Mol Vis. 2005 Aug 10;11:594-602

2005 | Samadi A, Cenedella RJ, Carlson CG. Diethylstilbestrol increases intracellular calcium in lens epithelial cells. Pflugers Arch. 2005 Jun;450(3):145-54. Epub 2005 May 5

2004 | Cenedella RJ, Jacob R, Borchman D, Tang D, Neely AR, Samadi A, Mason RP, Sexton P. Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor. J Lipid Res. 2004 Jul;45(7):1232-41. Epub 2004 Apr 21

2004 | Sexton PS, Neely AR, Cenedella RJ. Distribution of caveolin-1 in bovine lens and redistribution in cultured bovine lens epithelial cells upon confluence. Exp Eye Res. 2004 Jan;78(1):75-82

2003 | Cenedella RJ. Beware of combining erythromycin with a statin. J Am Osteopath Assoc. 2003 Mar;103(3):117

2003 | Cenedella RJ, Kuszak JR, Al-Ghoul KJ, Qin S, Sexton PS. Discordant expression of the sterol pathway in lens underlies simvastatin-induced cataracts in Chbb: Thom rats. J Lipid Res. 2003 Jan;44(1):198-211

2002 | Samadi A, Carlson CG, Gueorguiev A, Cenedella RJ. Rapid, non-genomic actions of progesterone and estradiol on steady-state calcium and resting calcium influx in lens epithelial cells. Pflugers Arch. 2002 Sep;444(6):700-9

2002 | Sexton PS, Cenedella RJ. Immunomagnetic capture of lens membrane fractions containing steroid binding protein. Biochem Biophys Res Commun 2002 Jul 26;295(4):1027-31

2001 | Cenedella RJ. Specific labeling of lens aldehyde dehydrogenase class 1 from (3)H-cholesterol or its derivatives. Ophthalmic Res 2001 Jul-Aug;33(4):210-6

2001 | Zhu XL, Sexton PS, Cenedella RJ. Characterization of membrane steroid binding protein mRNA and protein in lens epithelial cells. Exp Eye Res 2001 Aug;73(2):213-9

2001 | Jacob RF, Cenedella RJ, Mason RP. Evidence for distinct cholesterol domains in fiber cell membranes from cataractous human lenses. J Biol Chem 2001 Apr 27; 276(17):13573-8

2000 | Fliesler SJ, Richards MJ, Miller C, Peachey NS, Cenedella RJ. Retinal structure and function in an animal model that replicates the biochemical hallmarks of desmosterolosis. Neurochem Res 2000 May;25(5):685-94

2000 | Fliesler SJ, Richards MJ, Miller CY, Cenedella RJ. Cholesterol synthesis in the vertebrate retina: effects of U18666A on rat retinal structure, photoreceptor membrane assembly, and sterol metabolism and composition. Lipids 2000 Mar;35(3):289-96

1999 | Jacob RF, Cenedella RJ, Mason RP. Direct evidence for immiscible cholesterol domains in human ocular lens fiber cell plasma membranes. J Biol Chem 1999 Oct 29;274(44):31613-8

1999 | Cenedella RJ, Sexton PS, Zhu XL. Lens epithelia contain a high-affinity, membrane steroid hormone-binding protein. Invest Ophthalmol Vis Sci 1999 Jun;40(7):1452-9

1999 | Mitchell J, Cenedella RJ. Human lens cholesterol concentrations in patients who used lovastatin or simvastatin. Arch Ophthalmol 1999 May;117(5):653-7

1999 | Cenedella RJ, Chandrasekher G. Intense myristoylation of a single protein in the ocular lens. Biochem Biophys Res Commun 1999 Mar 24;256(3):652-6

1999 | Zhu XL, Cenedella RJ. Integrity and distribution of HMG CoA reductase mRNA in lens: relationship to cessation of membrane formation. Exp Eye Res 1999 Mar;68(3):371-3

1998 | Tang D, Borchman D, Yappert MC, Cenedella RJ. Influence of cholesterol on the interaction of alpha-crystallin with phospholipids. Exp Eye Res 1998 May;66(5):559-67

1998 | Cenedella RJ. Prenylation of proteins by the intact lens. Invest Ophthalmol Vis Sci 1998 Jun;39(7):1276-80

1998 | Cenedella RJ, Sexton PS. Probing cataractogenesis associated with mevalonic aciduria. Curr Eye Res 1998 Feb;17(2):153-8

1997 | Cenedella RJ. Posttranscriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in lens epithelial cells by mevalonate-derived nonsterols. Exp Eye Res 1997 Jul;65(1):63-72

1997 | Chandrasekher G, Cenedella RJ. Properties of alpha-crystallin bound to lens membrane: probing organization at the membrane surface. Exp Eye Res 1997 Mar;64(3):423-30

1997 | Fleschner CR, Cenedella RJ. Neutral lipids of the plasma membrane: composition of plasma membrane fractions isolated from ocular lens. Curr Eye Res 1997 Mar;16(3):263-9

1996 | Borchman D, Cenedella RJ, Lamba OP. Role of cholesterol in the structural order of lens membrane lipids. Exp Eye Res 1996 Feb;62(2):191-7

1996 | Cenedella RJ. Cholesterol and cataracts. Surv Ophthalmol 1996 Jan-Feb;40(4):320-37

1995 | Cenedella RJ. Role of transcription, translation, and protein turnover in controlling the distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the lens. Invest Ophthalmol Vis Sci 1995 Sep;36(10):2133-41

1995 | Chandrasekher G, Cenedella RJ. Protein associated with human lens 'native' membrane during aging and cataract formation. Exp Eye Res 1995 Jun;60(6):707-17

1995 | Mitchell J, Cenedella RJ. Quantitation of ultraviolet light-absorbing fractions of the cornea. Cornea 1995 May;14(3):266-72

1994 | Cenedella RJ, Shi H. Spatial distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase messenger RNA in the ocular lens: relationship to cholesterologenesis. J Lipid Res 1994 Dec;35(12):2232-40

1993 | Willingham, A.K., Bolanos, C., Bohannan, E. and Cenedella, R.J. The effects of high levels of vitamin E on the progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic Rabbit. The Journal of Nutritional Biochemistry 1993 4: 651-654

199 | Shi H, Cenedella RJ. Regional distribution of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and protein mass in the ocular lens. J Lipid Res 1993 Dec;34(12):2177-82

1993 | Chandrasekher G, Cenedella RJ. Calcium activated proteolysis and protein modification in the U18666A cataract. Exp Eye Res 1993 Dec;57(6):737-45

1993 | Cenedella RJ, Chandrasekher G. High capacity binding of alpha crystallins to various bovine lens membrane preparations. Curr Eye Res 1993 Nov;12(11):1025-38

1993 | Fleschner CR, Cenedella RJ. Isolation of a non-sedimenting membrane fraction from the water soluble fraction of bovine lens. Exp Eye Res 1993 Jun;56(6):649-57

1993 | Cenedella RJ. Apparent coordination of plasma membrane component synthesis in the lens. Invest Ophthalmol Vis Sci 1993 Jun;34(7):2186-94

1993 | Cenedella RJ, Mitchell J. Antagonism of [3H]fatty acid incorporation into vimentin by sodium pyruvate: pitfalls of protein acylation. Lipids 1993 Mar;28(3):235-40

1992 | Cenedella RJ, Linton LL, Moore CP. Cholesterylene, a newly recognized tissue lipid, found at high levels in the cornea. Biochem Biophys Res Commun 1992 Aug 14;186(3):1647-55

1992 | Cenedella RJ, Fleschner CR. Selective association of crystallins with lens 'native' membrane during dynamic cataractogenesis. Curr Eye Res 1992 Aug;11(8):801-15

1992 | Fleschner CR, Cenedella RJ. Examination of a lens 'native' plasma membrane fraction and its associated crystallins. Curr Eye Res 1992 Aug;11(8):739-52

1991 | Fleschner CR, Cenedella RJ. Lipid composition of lens plasma membrane fractions enriched in fiber junctions. J Lipid Res 1991 Jan;32(1):45-53

1990 | Cenedella RJ, Fleschner CR. Kinetics of corneal epithelium turnover in vivo. Studies of lovastatin. Invest Ophthalmol Vis Sci 1990 Oct;31(10):1957-62

1990 | Cenedella RJ, Augusteyn RC. On the composition and origin of the urea-soluble polypeptides of the U18666A cataract. Curr Eye Res 1990 Sep;9(9):805-18

1990 | Cenedella RJ. Palmitoylation of ocular lens membrane proteins. Invest Ophthalmol Vis Sci 1990 Feb;31(2):368-73

1989 | Cenedella RJ, Fleschner CR. Cholesterol biosynthesis by the cornea. Comparison of rates of sterol synthesis with accumulation during early development. J Lipid Res 1989 Jul;30(7):1079-84

1989 | Cenedella RJ. Cell cycle specific effects of selenium on the lens epithelium studied in vivo by the direct chemical approach. Curr Eye Res 1989 Apr;8(4):429-33

1989 | Cenedella RJ. Aging and rates of lens-cell differentiation in vivo, measured by a chemical approach. Invest Ophthalmol Vis Sci 1989 Mar;30(3):575-9

1988 | Fleschner CR, Cenedella RJ. Specific restriction of cholesterol from cortical lens gap junctional membrane in the U18666A cataract. Curr Eye Res 1988 Oct;7(10):1029-34

1988 | Kuszak JR, Khan AR, Cenedella RJ. An ultrastructural analysis of plasma membrane in the U18666A cataract. Invest Ophthalmol Vis Sci 1988 Feb;29(2):261-7

1987 | Rintoul DA, Cundy KV, Cenedella RJ. Physical properties of membranes and membrane lipids from the fiber cell of the U18666A-cataractous rat. Curr Eye Res 1987 Nov;6(11):1343-8

1987 | el-Sayed GN, Cenedella RJ. Relationship of cholesterolgenesis to DNA synthesis and proliferation by lens epithelial cells in culture. Exp Eye Res 1987 Sep;45(3):443-51

1987 | Hitchener WR, Cenedella RJ. HMG CoA reductase activity of lens epithelial cells: compared with true rates of sterol synthesis. Curr Eye Res 1987 Aug;6(8):1045-9

1987 | Cenedella RJ. Direct chemical measurement of DNA synthesis and net rates of differentiation of rat lens epithelial cells in vivo: applied to the selenium cataract. Exp Eye Res 1987 May;44(5):677-90

1987 | Cenedella RJ. Inhibitors of cholesterol synthesis and cataracts. JAMA 1987 Mar 27;257(12):1602

1985 | Hitchener WR, Cenedella RJ. Absolute rates of sterol synthesis estimated from [3H]water for bovine lens epithelial cells in culture. J Lipid Res 1985 Dec;26(12):1455-63

1985 | Alcala J, Cenedella RJ, Katar M. Limited proteolysis of MP26 in lens fiber plasma membranes of the U18666A-induced cataract in rats. Curr Eye Res 1985 Sep;4(9):1001-5

1985 | Cenedella RJ. Regional distribution of lipids and phospholipase A2 activity in normal and cataractous rat lens. Curr Eye Res 1985 Feb;4(2):113-20

1984 | Cenedella RJ. Lipoproteins and lipids in cow and human aqueous humor. Biochim Biophys Acta 1984 May 11;793(3):448-54

1984 | Cenedella RJ, Sarkar CP. Mechanism of depression of brain phospholipid levels by an epileptogenic drug. Biochem Pharmacol 1984 Feb 15;33(4):591-8

1984 | Cenedella RJ. Regional distribution of sterol and fatty acid synthesis in the ocular lens. Exp Eye Res 1984 Jan;38(1):95-9

1983 | Cenedella RJ. Source of cholesterol for the ocular lens, studied with U18666A: a cataract-producing inhibitor of lipid metabolism. Exp Eye Res 1983 Jul;37(1):33-43

1982 | Sarkar CP, Cenedella RJ. Gangliosides in normal and cataractous lenses of several species. Biochim Biophys Acta 1982 Jun 11;711(3):503-8

1982 | Cenedella RJ, Sarkar CP, Towns L. Studies on the mechanism of the epileptiform activity induced by U18666A. II. Concentration, half-life and distribution of radiolabeled U18666A in the brain. Epilepsia 1982 Jun;23(3):257-68

1982 | Sarkar CP, Bierkamper GG, Cenedella RJ. Studies on the mechanisms of the epileptiform activity induced by U186661. I Gross alteration of the lipids of synaptosomes and myelin. Epilepsia 1982 Jun;23(3):243-55

1982 | Cenedella RJ. Digitonide precipitable sterols: a reevaluation with special attention to lanosterol. Lipids 1982 Jun;17(6):443-7

1982 | Cenedella RJ. Sterol synthesis by the ocular lens of the rat during postnatal development. J Lipid Res 1982 May;23(4):619-26

1982 | Sarkar CP, Cenedella RJ. Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol. Lipids 1982 Jan;17(1):46-9

1981 | Cenedella RJ, Belis JA. Studies on the source of urinary cholesterol in the normal human male. J Lipid Res 1981 Jan;22(1):122-30

1980 | Cenedella RJ. Concentration-dependent effects of AY-9944 and U18666A on sterol synthesis in brain. Variable sensitivities of metabolic steps. Biochem Pharmacol 1980 Oct 15;29(20):2751-4

1979 | Cenedella RJ. Composition and synthesis in vivo of water-soluble proteins in the rat ocular lens: normal and cataractous. Exp Eye Res 1979 Dec;29(6):655-62

1979 | Cenedella RJ, Bierkamper GG. Mechanism of cataract production by 3-beta(2-diethylaminoethoxy) androst-5-en-17-one hydrochloride, U18666A: an inhibitor of cholesterol biosynthesis. Exp Eye Res 1979 Jun;28(6):673-88

1979 | Belis JA, Cenedella RJ. Urinary nonesterified cholesterol excretion in adenocarcinoma of the prostate. Cancer 1979 May;43(5):1840-6

1978 | Bierkamper GG, Cenedella RJ. Induction of chronic epileptiform activity in the rat by an inhibitor of cholesterol synthesis, U18666A. Brain Res 1978 Jul 14;150(2):343-51

1978 | Bierkamper GG, Cenedella RJ. Cerebral cortical cholesterol changes in cobalt-induced epilepsy. Epilepsia 1978 Apr;19(2):155-67

1977 | Kralovic RC, Zepp FA, Cenedella RJ. Studies of the mechanism of carcass fat depletion in experimental cancer. Eur J Cancer 1977 Oct;13(10):1071-9

1976 | Cenedella RJ. Hepatic triglyceride lipases--effect of clofibrate and halofenate. Biochem Pharmacol 1976 Dec 1;25(23):2657-61

1976 | Crouthamel WG. Halofenate and clofibrate: mechanism of hypotriglyceridemic action in the rat. J Lipid Res 1976 Mar;17(2):156-66

1976 | Galli C, Spagnuolo C, Rodriguez M, Cenedella RJ. Dietary induced modifications of brain polyunsaturated fatty acids and changes of free arachidonic acid release during ischaemia. Adv Exp Med Biol 1976;72:337-46

1975 | Cenedella RJ, Crouthamel WG, Bierkamper GG, Westfall DP. Alteration of drug pharmacodynamics by hyperlipidemia. Arch Int Pharmacodyn Ther 1975 Dec;218(2):299-311

1975 | Cenedella RJ, Galli C, Paoletti R. Brain free fatty levels in rats sacrificed by decapitation versus focused microwave irradiation. Lipids 1975 May;10(5):290-3

1975 | Crouthamel WG, Cenedella RJ. Clofibrate pharmacokinetics: effect of elevation of plasma-free fatty acids. Pharmacology 1975;13(5):465-73

1974 | Cenedella RJ, Imrich BJ. Lipolytic activities of intact Walker 256 ascites tumor cells. Lipids 1974 May;9(5):338-45

1974 | Cenedella RJ, Crouthamel WG. Intestinal versus hepatic contribution to circulating triglyceride levels. Lipids 1974 Jan;9(1):35-42

1973 | Cenedella RJ, Craig CR. Changes in cerebral cortical lipids in cobalt-induced epilepsy. J Neurochem 1973 Oct;21(4):743-8

1973 | Cenedella RJ, Crouthamel WG. Effect of aspirin upon male mouse fertility. Prostaglandins 1973 Aug;4(2):285-90

1973 | Braganza AF, Peterson RA, Cenedella RJ. The effects of heat and glucagon on the plasma glucose and free fatty acids of the domestic fowl. Poult Sci 1973 Jan;52(1):58-63

1972 | Cenedella RJ. Clofibrate and nafenopin (SU-13437): effects on plasma clearance and tissue distribution of chylomicron triglyceride in the dog. Lipids 1972 Oct;7(10):644-52

1972 | Beckett RB, Weiss R, Stitzel RE, Cenedella RJ. Studies on the hepatomegaly caused by the hypolipidemic drugs nafenopin and clofibrate. Toxicol Appl Pharmacol 1972 Sep;23(1):42-53

1972 | Wilson L Jr, Butcher RL, Cenedella RJ, Inskeep EK. Effects of progesterone on endometrial prostaglandins in sheep. Prostaglandins 1972 Mar;1(3):183-90

1972 | Wilson L Jr, Cenedella RJ, Butcher RL, Inskeep EK. Levels of prostaglandins in the uterine endometrium during the ovine estrous cycle. J Anim Sci 1972 Jan;34(1):93-9

1971 | Cenedella RJ, Saxe LH. Partial reversal of the in vivo antimalarial activity of DDS against Plasmodium berghei by induced hyperglycemia. Am J Trop Med Hyg 1971 Jul;20(4):530-4

1971 | Cenedella RJ. Effects of Su-13437, a new hypolipidemic drug, upon synthesis in vivo of hepatic and carcass total fatty acids and total cholesterol. Lipids 1971 Jul;6(7):475-80

1971 | Wagner WD, Peterson RA, Cenedella RJ. The effects of cold and prostaglandin E1 on lipid mobilization in the chicken. Can J Physiol Pharmacol 1971 May;49(5):394-8

1971 | Cenedella RJ. The lipids of the female monarch butterfly, Danaus plexippus, during fall migration. Insect Biochemistry 1971 1:244-247

1970 | Van Dyke K, Szustkiewicz C, Cenedella RJ, Saxe LH. An automated method of mass drug testing applied to screening for antimalarial activity. Chemotherapy 1970 15: 177-188

Books, Chapters, and Reviews:

2002 | Cenedella RJ. 2002. Hypocholesterolemic drugs and coronary heart disease, In Modern Pharmacology with Clinical Applications (C.R. Craig and R. Stitzel, eds), Lippincott, Williams and Wilkins, Chapter 23.

1997 | Cenedella RJ. 1997. Cholesterol and hypocholesterolemic drugs, In Modern Pharmacology (C. Craig and R. Stitzel, eds), 5th Edition, Little Brown, Boston, MA.

1994 | Cenedella RJ. 1994. Cholesterol and hypocholesterolemic drugs, In Modern Pharmacology (C. Craig and R. Stitzel, eds), 4th Edition, Little Brown, Boston, MA, p. 197-209.

1990 | Cenedella RJ. 1990. Cholesterol and hypocholesterolemic drugs, In Medical Pharmacology, 3rd Edition (R. Stitzel and R. Craig, eds.), Little, Brown & Co., Boston, MA, p. 234-247

1986 | Cenedella RJ. 1986. Cholesterol and hypocholesterolemia drugs, In Medical Pharmacology, 2nd Edition (R. Stitzel and R. Craig, eds.), Little, Brown & Co., Boston, MA, p. 329-344.

1983 | Cenedella RJ, Sarkar CP, Bierkamper GG. 1983 Altered Cerebral Lipids as the Basis of Some Epilepsies. In Molecular Aspects of Neurological Disorders (L. Austin, ed.). Academic Press, Australia, p. 307-310.

1982 | Cenedella RJ. 1982. Cholesterol and hypocholesterolemia drugs, In Medical Pharmacology, 1st Edition (R. Stitzel and R. Craig, eds.), Little, Brown & Co., Boston, MA, p. 295-307.

1975 | Cenedella RJ. Prostaglandins and male reproductive physiology. Adv Sex Horm Res 1975;1:325-58

1966 | Cenedella RJ, Saxe LH. 1966 Automated Mass Screening for Compounds for Antimalarial Activity. In Technicon Symposia, Automation in Analytical Chemistry, (L.T. Skeggs, Jr., ed.). Mediad Inc., New York, NY, p. 281-285.

Other Scholarly Publications:

1986 | Cenedella RJ, Willingham AK. Rapid Review of Human Biochemistry, (R.J. Cenedella, ed.) KCOM Press, Kirksville, MO, 3rd Edition, 1986

1985 | Cenedella RJ, Awad AB, Willingham AK, Yannarell A, Zepp EA. Rapid Review of Human Biochemistry, (R.J. Cenedella, ed.) KCOM Press, Kirksville, MO, 1st Edition, 1982, 2nd Edition, 1985